![]() In the proposed treatment, the cells are cultured for four to six weeks. A previous study using a rat model of cerebral infarction also showed that MSCs derived from rat and human cranial bones proved to be abundant with neurotrophic factors, proteins that strengthen neuron health and functional recovery. The researchers said that cranial bone-derived MSCs are superior to the ones isolated from the iliac bone, the most exploited source of MSCs, as they possess greater (1) expression of neurotrophic factors, (2) neuroprotective effect of culture supernatant, and (3) ability to differentiate into nerves. MSCs, which are multipotent and capable of developing specific kinds of cells, can be obtained from different sources, but their characteristics may vary depending on the tissue of origin. The novel stem cell treatment can offer hope for patients wanting to revert to how their body was pre-stroke, especially since, according to the researchers, stroke cases in Japan are expected to more than double from 1.3 million in 2019 to three million in 2025 as the population ages. ![]() Annually, medical expenses for stroke across Japan amount to approximately 1.8 trillion yen, while nursing care reaches an estimated 1.9 trillion yen in costs. Currently, stroke has no established treatment after the recovery period.Ī 2007 survey on living conditions by Japan’s Ministry of Health, Labour and Welfare showed that stroke was the top 2 cause of dementia and the need for nursing care in the nation and the leading reason behind becoming bedridden. Some of stroke’s sequelae include paralysis, speech impairment, cognitive decline, dysphagia or difficulty in swallowing, spasticity or muscle stiffness, depression, Parkinson’s syndrome, symptomatic epilepsy, and urinary disorders. Many moderate to severe stroke patients, whose brain pressure could not be controlled without removing the skull, end up with severe residual disabilities and require assistance and care in their daily lives. However, in patients with moderate to severe stroke, even if the surgery saves their lives, it could not repair the damage inflicted by the life-threatening condition on their brain tissues. In such an urgent situation, neurosurgeons have long performed extracranial decompression, reducing the increased pressure by removing a large area of the skull and replacing the dura mater with a substitute membrane, such as a periosteum or artificial dura mater. Cerebral infarction, which clinically manifests as ischemic stroke, happens when blood and oxygen supply to the brain is disrupted, most commonly due to a blood clot blocking blood vessels.Ī stroke can cause a build-up in intracranial pressure that may lead to lasting brain injury or even death. The proposed therapy uses patients’ own cultured MSCs taken from their cranial bone, known as autologous cranial bone-derived MSCs, as a treatment for moderate to severe cerebral infarction - from which neurological dysfunction recovery is extremely difficult with standard treatment. The three have been studying the use of MSCs for nerve regeneration therapy and have successfully demonstrated that cranial bone-derived MSCs effectively restored neurological function in rat models of brain infarction and spinal cord injury. Speaking at the conference were the HU researchers leading the clinical study - Department of Neurosurgery’s Professor Nobutaka Horie and Assistant Professor Takafumi Mitsuhara and Bio-Environmental Adaptation Sciences Professor Rui Yuge. The first patient in the trial received the initial intravenous dose of MSCs in August. HU made the announcement about the clinical trial on September 7. Hiroshima University (HU) started the human trial for a promising treatment that offers hope in potentially reversing paralysis and language disorder after moderate to severe stroke using therapeutically superior mesenchymal stem cells (MSCs) derived from the cranial bone.
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